The strong specific binding of radicicol to heat shock protein 90 (HSP90) leads to deregulation of its target mechanisms: cell cycle, cell proliferation, apoptosis/cell vitality. Also binds to yeast HSP90, E.coli HtpG and TRAP-1. Antifungal effects are probably caused by inactivation of chitin synthase in fungal cells.
Working concentration: 5-300 µM
Assay (HPLC) | ≥98 % |