monoclonal de souris anti-kératine K17, Ks17.E3, 1 ml

This antibody portfolio includes a wide range of tissue- & tumor-specific primary antibodies for basic research, product development and analysis of a variety of biological questions. The monoclonal antibodies are perfectly applicable for all cell or tissue biology studies and for the analysis of predictive markers in research.

Ks 17.E3 represents an excellent marker to distinguish myoepithelial cells (positive for K17) from luminal epithelium of various glands (mammary, sweat, salivary, bronchial, tracheal, laryngeal, esophageal) and benign from malignant forms of e.g. mammary gland tumors. In the epidermis suprabasal staining is found only in cornifying regions and in the outer root sheath of hair follicles.

Tested reactivity on cultured cell lines: HeLa, A-431.

Tumors specifically detected: benign tumors of mammary gland; most malignant forms of mammary tumors are negative for keratin K17.

Host: mouse
Antibody type: monoclonal
Isotype: IgG2b
Clone: Ks17.E3
Immunogen: human keratin K17 of 46 kDa
UniprotID: Q04695 (human),Q6IFU8 (rat)
Synonym: keratin, type I cytoskeletal 17, 39.1, cytokeratin-17, CK-17, keratin-17, K17, KRT17
Conjugate: unconjugated
Purification: affinity chromatography
Intended use: research use only
Application: IHC, WB
Reactivity: human, rat

Immunohistochemistry (IHC) - frozen: 1:10-1:50
Immunohistochemistry (IHC) - paraffin: 1:10-1:50 (microwave treatment recommended)
Western Blot (WB): 1:100 (0.5 µg/ml)