Isolated from streptomoycin and other actinomycetes.
Strong, highly selective inhibition. Inhibits pepsin, renin, cathepsin D, chymosin, protease B and also retroviral proteases. No inhibitive effect on thiolproteases, neutral proteases and serine proteases.
Hardly toxic.
Working concentration: 0.5-1 µM.
It may be necessary to add 10-50 % acetic acid to completely dissolve pepstatin A.
Appearance | white powder |
Assay (HPLC) | ≥98 % |
Specific rotation [α]20D (c=0,5 in methanol) | -97° to -89° |